Trimethoprim/sulfadoxine
| Combination of | |
|---|---|
| Trimethoprim | Dihydrofolate reductase inhibitor |
| Sulfadoxine | Sulfonamide antibiotic |
| Clinical data | |
| Trade names | Trimidox |
| Identifiers | |
| CAS Number | |
Trimethoprim/sulfadoxine, sold under the brand name Trimidox, is an antibacterial agent that is used in cattle and swine to prevent and treat infections by both Gram-negative and Gram-positive bacteria.
Veterinary uses
Trimethoprim/sulfadoxine is used in the treatment of swine and cattle; including dairy cattle, beef cattle and veal.
In cattle, it is used to treat:
- Respiratory tract infections such as, bovine pneumonia pasteurellosis (shipping fever)
- Alimentary tract infections such as salmonellosis and both enteric and septicaemic colibacillosis.
- Other infections such as pododermatitis (foot rot) and septicaemias.
In swine, it is used to treat:
- Respiratory tract infections such as, bacterial pneumonias.
- Alimentary tract infections such as, post-weaning scours and colibacillosis.
- Other infections such as bacterial arthritis and mastitis-metritis-agalactia syndrome in sows.
Contraindications
Trimethoprim/sulfadoxine is contraindicated in cattle or swine that show marked liver parenchymal damage or blood dyscrasias, or those with a history of sulfonamide sensitivity.
Milk from an animal treated with trimethoprim/sulfadoxine must not be consumed for at least 96 hours following the most recent treatment; treated animals must not be slaughtered for use in food for at least ten days after the last treatment.