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Ophthalmology drugs
Unoprostone
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Unoprostone

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Unoprostone
Unoprostone.svg
Clinical data
Trade names Rescula
AHFS/Drugs.com Micromedex Detailed Consumer Information
Routes of
administration		 Topical (eye drops)
ATC code
Legal status
Legal status
  • US: Discontinued
Pharmacokinetic data
Elimination half-life 14 min
Excretion Renal
Identifiers
  • (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl)
    cyclopentyl]hept-5-enoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.227.145
Chemical and physical data
Formula C22H38O5
Molar mass 382.541 g·mol−1
3D model (JSmol)
  • O=C(O)CCC/C=C\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCCCCCC
  • InChI=1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1 ☒N
  • Key:TVHAZVBUYQMHBC-SNHXEXRGSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, was marketed under the trade name Rescula for the management of open-angle glaucoma and ocular hypertension.

It was approved by the Food and Drug Administration in 2000.

In 2009, Sucampo Pharmaceuticals acquired the rights to the drug in the U.S. and Canada.

In 2015, the drug was discontinued in the U.S.


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