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Cholera
Virstatin
Другие языки:

    Virstatin

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    Virstatin
    Virstatin.jpg
    Identifiers
    • 4-(N-(1,8-naphthalimide))-n-butyric acid
    CAS Number
    PubChem CID
    ChemSpider
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C16H13NO4
    Molar mass 283.283 g·mol−1
    3D model (JSmol)
    Density 1.40 g/cm3
    Melting point 180–183 °C (356–361 °F)
    Boiling point 536.52 °C (997.74 °F)
    • c1cc2cccc3c2c(c1)C(=O)N(C3=O)CCCC(=O)O
    • InChI=1S/C16H13NO4/c18-13(19)8-3-9-17-15(20)11-6-1-4-10-5-2-7-12(14(10)11)16(17)21/h1-2,4-7H,3,8-9H2,(H,18,19)
    • Key:ZHXRDXTYPCPBTI-UHFFFAOYSA-N

    Virstatin is a small molecule that inhibits the activity of the cholera protein, ToxT.

    Its activity in cholera was first published in 2005 in a paper that described the screening of a chemical library in a phenotypic screen and subsequent testing of one of the hits in infected mice.

    Reaction scheme used in original discovery and analysis of the molecule

    The compound is an isoquinoline alkaloid and can be synthesized by a simple two-step synthesis


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