Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.
Experimental drugs
ZINC17988990
Другие языки:

    ZINC17988990

    Подписчиков: 0, рейтинг: 0
    ZINC17988990
    ZINC17988990 structure.png
    Identifiers
    • (4-oxo-5-phenyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl 3-(3-oxo-1,4-benzoxazin-4-yl)propanoate
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C24H19N3O5S
    Molar mass 461.49 g·mol−1
    3D model (JSmol)
    • C1C(=O)N(C2=CC=CC=C2O1)CCC(=O)OCC3=NC4=C(C(=CS4)C5=CC=CC=C5)C(=O)N3
    • InChI=1S/C24H19N3O5S/c28-20-13-31-18-9-5-4-8-17(18)27(20)11-10-21(29)32-12-19-25-23(30)22-16(14-33-24(22)26-19)15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,25,26,30)
    • Key:YOFCRYWWKQMPEW-UHFFFAOYSA-N

    ZINC17988990 is a drug which acts as a potent and selective inhibitor for the TRPV5 calcium channel, with an IC50 of 177 nM and high selectivity for TRPV5 over TRPV6 and the other subtypes of TRPV. It is the first selective inhibitor to be developed for TRPV5, and may be useful for modulating calcium reabsorption in the kidneys.

    See also



    Новое сообщение