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Acediasulfone
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ECHA InfoCard | 100.001.131 |
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Formula | C14H14N2O4S |
Molar mass | 306.34 g·mol−1 |
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Acediasulfone (INN) is an antimicrobial drug, which also has antimalarial activity. It is a long-acting prodrug of dapsone, which is used for treating leprosy.
Synthesis
Dapsone is somewhat inconvenient to administer to patients because of its rather low water solubility.

Acediasulfone synthesis:CH 254803 and CH 278482 (1949, 1952, to Cilag Ltd.); Rawlins, U.S. Patent 2,589,211 (1952 to Parke-Davis).
In the search for more easily administered drugs, dapsone (1) was reacted with bromoacetic acid to give acediasulfone (2) which can be administered as a water-soluble salt.