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Antibiotic
Actinobolin
Другие языки:

    Actinobolin

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    Actinobolin
    Actinobolin.svg
    Names
    IUPAC name
    (2S)-2-Amino-N-[(3R,4R,4aR,5R,6R)-5,6,8-trihydroxy-3-methyl-1-oxo-3,4,4a,5,6,7-hexahydroisochromen-4-yl]propanamide
    Other names
    (Propanamide, 2-amino-N-(3,4,4a,5,6,7-hexahydro-5,6, 8-trihydroxy-3-met hyl-1-oxo-1H-2-benzopyran-4-yl)-
    Identifiers
    3D model (JSmol)
    ChEMBL
    ChemSpider
    PubChem CID
    UNII
    • InChI=1S/C13H20N2O6/c1-4(14)12(19)15-10-5(2)21-13(20)8-6(16)3-7(17)11(18)9(8)10/h4-5,7,9-11,16-18H,3,14H2,1-2H3,(H,15,19)/t4-,5+,7+,9+,10-,11-/m0/s1
      Key: PQVQBAAWCOTEBG-NSVWQLETSA-N
    • CC1C(C2C(C(CC(=C2C(=O)O1)O)O)O)NC(=O)C(C)N
    Properties
    C13H20N2O2
    Molar mass 236.315 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Actinobolin is a antibiotic with the molecular formula C13H20N2O6. Actinobolin is produced by the bacterium Streptomyces griseoviridus var atrofaciens.

    Further reading

    • Tharra, Prabhakara R.; Mikhaylov, Andrey A.; Švejkar, Jiří; Gysin, Marina; Hobbie, Sven N.; Švenda, Jakub (28 February 2022). "Short Synthesis of (+)‐Actinobolin: Simple Entry to Complex Small‐Molecule Inhibitors of Protein Synthesis". Angewandte Chemie International Edition. doi:10.1002/anie.202116520.
    • Antimicrobial Agents and Chemotherapy. 1958. p. 503.
    • Munk, Morton E.; Sodano, Charles S.; McLean, Robert L.; Haskell, Theodore H. (August 1967). "Actinobolin. I. Structure of actinobolamine". Journal of the American Chemical Society. 89 (16): 4158–4165. doi:10.1021/ja00992a034.



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