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Alglucerase
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Alglucerase

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Alglucerase
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a692001
ATC code
Pharmacokinetic data
Elimination half-life 3.6–10.4 min
Identifiers
  • Human beta-glucocerebrosidase
CAS Number
DrugBank
ChemSpider
  • none
UNII
KEGG
ChEMBL
Chemical and physical data
Formula C2532H3854N672O711S16
Molar mass 55597.64 g·mol−1
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Alglucerase was a biopharmaceutical drug for the treatment of Gaucher's disease. It was a modified form of human β-glucocerebrosidase enzyme, where the non-reducing ends of the oligosaccharide chains have been terminated with mannose residues.

Ceredase is the trade name of a citrate buffered solution of alglucerase that was manufactured by Genzyme Corporation from human placental tissue. It is given intravenously in the treatment of Type 1 Gaucher's disease. This was the first drug approved as an enzyme replacement therapy.

It was approved by the FDA in 1991. It has been withdrawn from the market due to the approval of similar drugs made with recombinant DNA technology instead of being harvested from tissue; drugs made recombinantly, since there is no concern about diseases being transmitted from the tissue used in harvesting, and are less expensive to manufacture (see imiglucerase).

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