Мы используем файлы cookie.
Продолжая использовать сайт, вы даете свое согласие на работу с этими файлами.

Aloxistatin

Другие языки:

Aloxistatin

Подписчиков: 0, рейтинг: 0

Aloxistatin
Clinical data

ATC code	none
Legal status
Legal status	US: Investigational drug
Identifiers
IUPAC name ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
CAS Number	88321-09-9
PubChem CID	65663
ChemSpider	59098
UNII	L5W337AOUR
ChEBI	CHEBI:101381
ChEMBL	ChEMBL63440
CompTox Dashboard (EPA)	DTXSID00904150
ECHA InfoCard	100.163.683
Chemical and physical data
Formula	C₁₇H₃₀N₂O₅
Molar mass	342.436 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
InChI InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 Key:SRVFFFJZQVENJC-IHRRRGAJSA-N

Aloxistatin (loxistatin, E-64d, EST) is a drug which acts as a cysteine protease inhibitor and has anticoagulant effects. It is a synthetic analogue of E-64, a natural product derived from fungi. It was researched for the treatment of muscular dystrophy but was not successful in human clinical trials, though it has continued to be investigated for treatment of spinal cord injury, stroke and Alzheimer's disease. It also shows antiviral effects.