Amiphenazole

Amiphenazole

Clinical data
ATC code	none
Legal status
Legal status	AU: S4 (Prescription only)
Identifiers
IUPAC name 5-phenyl-1,3-thiazole-2,4-diamine
CAS Number	490-55-1
PubChem CID	10275
ChemSpider	9855 Y
UNII	7ZJ8PWY0XD
ChEMBL	ChEMBL1514085
CompTox Dashboard (EPA)	DTXSID7046388
ECHA InfoCard	100.007.013
Chemical and physical data
Formula	C9H9N3S
Molar mass	191.25 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=C(N=C(S2)N)N
InChI InChI=1S/C9H9N3S/c10-8-7(13-9(11)12-8)6-4-2-1-3-5-6/h1-5H,10H2,(H2,11,12) Y Key:UPOYFZYFGWBUKL-UHFFFAOYSA-N Y
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Amiphenazole (Daptazile) is a respiratory stimulant traditionally used as an antidote for barbiturate or opiate overdose, usually in combination with bemegride, as well as poisoning from other sedative drugs and treatment of respiratory failure from other causes. It was considered particularly useful as it could counteract the sedation and respiratory depression produced by morphine but with less effect on analgesia. It is still rarely used in medicine in some countries, although it has largely been replaced by more effective respiratory stimulants such as doxapram and specific opioid antagonists such as naloxone.