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Antiinfective agent stubs
Amoscanate
Другие языки:

    Amoscanate

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    Amoscanate
    Skeletal formula
    Space-filling model
    Names
    Preferred IUPAC name
    4-Isothiocyanato-N-(4-nitrophenyl)aniline
    Other names
    4-Isothiocyanato-4′-nitrodiphenylamine
    Nithiocyamine
    Identifiers
    3D model (JSmol)
    ChEBI
    ChEMBL
    ChemSpider
    PubChem CID
    UNII
    • InChI=1S/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H checkY
      Key: DKVNAGXPRSYHLB-UHFFFAOYSA-N checkY
    • InChI=1/C13H9N3O2S/c17-16(18)13-7-5-12(6-8-13)15-11-3-1-10(2-4-11)14-9-19/h1-8,15H
    • O=N(=O)c1ccc(Nc2ccc(cc2)N=C=S)cc1
    • [O-] [N+](=O)c1ccc(cc1)Nc2ccc(N=C=S)cc2
    Properties
    C13H9N3O2S
    Molar mass 271.29 g·mol−1
    Melting point 204 to 206 °C (399 to 403 °F; 477 to 479 K)
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
    checkY verify (what is checkY☒N ?)

    Amoscanate (INN), also known as nithiocyamine, is an experimental anthelmintic agent of the aryl isothiocyanate class which was found to be highly effective in animals against the four major species of schistosomes which infect humans, and is also highly active against hookworm infection. However, significant liver toxicity was seen in lab animals at higher doses. The ether analogue of amoscanate, nitroscanate, is used in veterinary medicine as an anthelmintic.

    Amoscanate was developed by Ciba.



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