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Antiviral drug
Apoptozole
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    Apoptozole

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    Apoptozole
    Apoptozole structure.png
    Clinical data
    Trade names Apoptozole
    Identifiers
    • 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)imidazol-1-yl]methyl]benzamide
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C33H25F6N3O3
    Molar mass 625.6 g·mol−1
    3D model (JSmol)
    • COC1=CC=C(C=C1)C2=C(N(C(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)CC4=CC=C(C=C4)C(=O)N)C5=CC=C(C=C5)OC
    • InChI=1S/C33H25F6N3O3/c1-44-26-11-7-20(8-12-26)28-29(21-9-13-27(45-2)14-10-21)42(18-19-3-5-22(6-4-19)30(40)43)31(41-28)23-15-24(32(34,35)36)17-25(16-23)33(37,38)39/h3-17H,18H2,1-2H3,(H2,40,43)
    • Key:ZIMMTPFXOMAJTQ-UHFFFAOYSA-N

    Apoptozole is a drug that acts as a potent and selective inhibitor of the heat shock protein Hsp70, and was one of the first compounds developed to act at this target. It induces apoptosis in susceptible cells, and displays anti-cancer, anti-malarial and antiviral activity. The promising results in animal studies makes it likely that either apoptozole or compounds with similar modes of action will be further researched as potential therapeutics in the future.


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