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Experimental drugs
AT-121
Другие языки:

    AT-121

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    AT-121
    AT-121.svg
    Legal status
    Legal status
    • Investigational
    Identifiers
    • 3-oxo-1'-(4-propan-2-ylcyclohexyl)-2-[2-(sulfamoylamino)ethyl]spiro[1H-isoquinoline-4,4'-piperidine]
    CAS Number
    PubChem CID
    Chemical and physical data
    Formula C24H38N4O3S
    Molar mass 462.65 g·mol−1
    3D model (JSmol)
    • CC(C)[C@H]1CC[C@H](CC1)N1CCC2(CC1)C(=O)N(CCNS(N)(=O)=O)CC1=CC=CC=C21

    AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor. The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids. A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.

    See also


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