Avatrombopag

Avatrombopag

Clinical data
Pronunciation	a" va trom' boe pag
Trade names	Doptelet
AHFS/Drugs.com	Monograph
MedlinePlus	a618032
License data	EU EMA: by INN US DailyMed: Avatrombopag
Pregnancy category	AU: B3
Routes of administration	By mouth
ATC code	B02BX08 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) US: ℞-only EU: Rx-only In general: ℞ (Prescription only)
Identifiers
IUPAC name 1-[3-Chloro-5-[[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl]pyridin-2-yl]piperidine-4-carboxylic acid
CAS Number	570406-98-3 N
PubChem CID	9852519
DrugBank	DB11995 Y
ChemSpider	8028230 Y
UNII	3H8GSZ4SQL
KEGG	D10306 as salt: D10307
ChEMBL	ChEMBL2103883 N
CompTox Dashboard (EPA)	DTXSID30205667
Chemical and physical data
Formula	C29H34Cl2N6O3S2
Molar mass	649.65 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
InChI InChI=1S/C29H34Cl2N6O3S2/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38) Y Key:OFZJKCQENFPZBH-UHFFFAOYSA-N
NY (what is this?)

Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure. It was approved for medical use in the United States in May 2018, the European Union in June 2019, and Australia in January 2023.

It acts as a thrombopoietin receptor agonist.

External links

• "Avatrombopag". Drug Information Portal. U.S. National Library of Medicine.