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Baccatin III
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Names | |
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IUPAC name
(2β,5α,7α,10α,13β)-4,10-Diacetoxy-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard | 100.164.451 |
PubChem CID
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UNII | |
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Properties | |
C31H38O11 | |
Molar mass | 586.62677 Da |
Melting point | 229 to 234 °C (444 to 453 °F; 502 to 507 K) |
Acidity (pKa) | 12.76 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Baccatin III is an isolate from the yew tree (Genera Taxus). Baccatin III is a precursor to the anti-cancer drug paclitaxel (Taxol).
In 2014, researchers reported introduction and expression of the endophytic fungal gene responsible for synthesizing baccatin III (10-deacetylbaccatin III 10-O-acetyltransferase), to the mushroom Flammulina velutipes. Researchers achieved the same accomplishment with Escherichia coli in 2000.