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Antidote
Bentracimab
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    Bentracimab

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    "REVERSE-IT" redirects here. For the Himiko Kikuchi album, see Himiko Kikuchi.
    Bentracimab
    Monoclonal antibody
    Type Fab fragment
    Source Human
    Target Ticagrelor, AR-C124910XX (the active metabolite)
    Clinical data
    Other names PB2452, MEDI2452
    Routes of
    administration    		 Intravenous infusion
    ATC code
    • None
    Legal status
    Legal status
    • Investigational
    Identifiers
    CAS Number
    PubChem SID
    DrugBank
    UNII
    KEGG
    Chemical and physical data
    Formula C2095H3240N560O674S12
    Molar mass 47440.93 g·mol−1

    Bentracimab is a monoclonal antibody medication which has been shown in phase one and two clinical trials to function as a reversal agent for the anti–blood clotting drug ticagrelor (which acts as a P2Y12 inhibitor and is sold under the brand name Brilinta among others). It is under investigation for use in major, life-threatening bleeding in patients being treated with ticagrelor. It is not commercially available.

    See also



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