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Drugs with unknown mechanisms of action
Budipine
Другие языки:

Budipine

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Budipine
Budipine.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Identifiers
  • 1-tert-butyl-4,4-diphenylpiperidine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.055.494
Chemical and physical data
Formula C21H27N
Molar mass 293.454 g·mol−1
3D model (JSmol)
  • c1(ccccc1)C3(c2ccccc2)CCN(C(C)(C)C)CC3
  • InChI=1S/C21H27N/c1-20(2,3)22-16-14-21(15-17-22,18-10-6-4-7-11-18)19-12-8-5-9-13-19/h4-13H,14-17H2,1-3H3 checkY
  • Key:QIHLUZAFSSMXHQ-UHFFFAOYSA-N checkY
  (verify)

Budipine (brand name Parkinsan) is an antiparkinson agent marketed for the treatment of Parkinson's disease.

While its exact mechanism of action is not well characterized, it is believed to be an NMDA receptor antagonist, but also promoting the synthesis of dopamine.

Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.

Synthesis

Budipine can be prepared from the 1-tert-butyl-4-piperidone [1465-76-5] directly by treatment with benzene in the presence triflic acid. This method of synthesis enables a 99% yield of product.

Thieme Synthesis:

4-Phenyl-1-t-butyl-4-piperidinol, (1)

1-t-butyl-3-benzoyl-4-phenyl-4-piperidinol [81831-81-4] (3)

See also


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