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Eli Lilly and Company
CECXG
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    CECXG

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    CECXG
    CECXG structure.png
    Identifiers
    • 2-(1'SR,2'SR,3'SR)-2'-carboxy-3'-ethylcyclopropyl-2-(9-xanthylmethyl)glycine
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C22H23NO5
    Molar mass 381.428 g·mol−1
    3D model (JSmol)
    • c4cccc2c4Oc3ccccc3C2CC(N)(C(O)=O)C1C(C(=O)O)C1CC
    • InChI=1S/C22H23NO5/c1-2-12-18(20(24)25)19(12)22(23,21(26)27)11-15-13-7-3-5-9-16(13)28-17-10-6-4-8-14(15)17/h3-10,12,15,18-19H,2,11,23H2,1H3,(H,24,25)(H,26,27)/t12-,18+,19+,22+/m1/s1 ☒N
    • Key:NBAKIHCDPVZWRB-KQLBNOIASA-N ☒N
     ☒NcheckY (what is this?)  (verify)

    CECXG (3'-ethyl-LY-341,495) is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), with reasonable selectivity for mGluR3. While it is some five times less potent than LY-341,495 at mGluR3, it has 38x higher affinity for mGluR3 over mGluR2, making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes.


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