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Experimental cancer drugs
Cerdulatinib
Другие языки:

Cerdulatinib

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Cerdulatinib
Cerdulatinib.svg
Clinical data
Other names PRT062070, PRT2070, DMVT-502
Routes of
administration		 By mouth
Identifiers
  • 4-(Cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C20H27N7O3S
Molar mass 445.54 g·mol−1
3D model (JSmol)
  • CCS(=O)(=O)N1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4CC4)C(=O)N
  • InChI=1S/C20H27N7O3S/c1-2-31(29,30)27-11-9-26(10-12-27)16-7-5-15(6-8-16)24-20-22-13-17(18(21)28)19(25-20)23-14-3-4-14/h5-8,13-14H,2-4,9-12H2,1H3,(H2,21,28)(H2,22,23,24,25) checkY
  • Key:BGLPECHZZQDNCD-UHFFFAOYSA-N

Cerdulatinib is a small molecule SYK/JAK kinase inhibitor in development for treatment of hematological malignancies. It has lowest nM IC50 values against TYK2, JAK1, JAK2, JAK3, FMS, and SYK.

It is being developed by Portola Pharmaceuticals; in September 2018 the FDA granted orphan drug status to cerdulatinib for the treatment of peripheral T-cell lymphoma (PTCL).

See also


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