Chimerin 1

chimerin (chimaerin) 1
Crystal structure of human chimerin 1 (CHN1)
Identifiers
Symbol	CHN1
Alt. symbols	CHN
NCBI gene	1123
HGNC	1943
OMIM	118423
RefSeq	NM_001822
UniProt	P15882
Other data
Locus	Chr. 2 q31-q32.1
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Chimerin 1 (CHN1), also known as alpha-1-chimerin, n-chimerin, is a protein which in humans is encoded by the CHN1 gene.

Chimerin 1 is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may be involved in signal transduction.

This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding.

Function

CHN1 is a three-domain protein with the N-terminal SH2 domain, the C-terminal RhoGAP domain and the central C1 domain similar to protein kinase C. When lipid diacylglycerol (DAG) binds to the C1 domain, CHN1 is transferred to the plasma membrane and negatively regulates Rho-family small GTPases RAC1 and CDC42, thus causing the morphological change of axons by pruning the ends of axon dendrites.

Mutational analysis suggests that un-overlapping residues of the RhoGAP domain are involved in RAC1-binding and the RAC1-GAP activity. Regulation of the RhoGAP activity of CHN1 by phorbol esters, natural compounds mimic of the lipid second messenger DAG, presents a possible way of designing agents for therapeutics.

Clinical significance

Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2).

External links

• GeneReviews/NCBI/NIH/UW entry on Duane syndrome
• Chimerin+1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.