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Experimental cancer drugs
Cryptolepine
Другие языки:

    Cryptolepine

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    Cryptolepine
    Cryptolepine.svg
    Names
    Preferred IUPAC name
    5-Methyl-5H-indolo[3,2-b]quinoline
    Identifiers
    3D model (JSmol)
    ChEBI
    ChEMBL
    ChemSpider
    KEGG
    PubChem CID
    UNII
    • InChI=1S/C16H12N2/c1-18-15-9-5-2-6-11(15)10-14-16(18)12-7-3-4-8-13(12)17-14/h2-10H,1H3
      Key: KURWKDDWCJELSV-UHFFFAOYSA-N
    • N2=C1C(C=CC=C1)=C4C2=Cc3ccccc3N4C
    Properties
    C16H12N2
    Molar mass 232.286 g·mol−1
    Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

    Cryptolepine is an alkaloid with antimalarial and cytotoxic properties, in vitro and in mice. It is able to intercalate into DNA at the cytosine-cytosine sites. Because of its toxicity, Cryptolepine is not considered appropriate for use as an anti-malarial drug in humans.

    Cryptolepine can be found in the roots of the West African plant, Cryptolepis sanguinolenta.



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