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Anti-diabetic drugs
Dapagliflozin/metformin
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    Dapagliflozin/metformin

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    Dapagliflozin/metformin
    Combination of
    Dapagliflozin SGLT2 inhibitor
    Metformin Anti-diabetic biguanide
    Clinical data
    Trade names Xigduo, Xigduo XR, Ebymect
    AHFS/Drugs.com Professional Drug Facts
    License data
    Routes of
    administration    		 By mouth
    ATC code
    Legal status
    Legal status
    • AU: S4 (Prescription only)
    • UK: POM (Prescription only)
    • US: ℞-only
    • EU: Rx-only
    • In general: ℞ (Prescription only)
    Identifiers
    CAS Number
    PubChem CID
    KEGG
    Chemical and physical data
    Formula C25H37Cl2N5O6
    Molar mass 574.50 g·mol−1
    3D model (JSmol)
    • CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)CO)O)O)O)Cl.CN(C)C(=N)N=C(N)N.Cl
    • InChI=1S/C21H25ClO6.C4H11N5.ClH/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21;1-9(2)4(7)8-3(5)6;/h3-8,10,17-21,23-26H,2,9,11H2,1H3;1-2H3,(H5,5,6,7,8);1H/t17-,18-,19+,20-,21?;;/m1../s1
    • Key:IPQABJMJAWNGON-RFSZPCNPSA-N

    Dapagliflozin/metformin, sold under the brand name Xigduo XR among others, is a fixed-dose combination anti-diabetic medication used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. It is a combination of dapagliflozin and metformin. Dapagliflozin/metformin was approved for use in the European Union in January 2014, and for use in the United States in February 2014. It is taken by mouth.

    Adverse effects

    To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA has approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to recommend they be stopped temporarily before scheduled surgery. Canagliflozin, dapagliflozin, and empagliflozin should each be stopped at least three days before, and ertugliflozin should be stopped at least four days before scheduled surgery.

    Symptoms of ketoacidosis include nausea, vomiting, abdominal pain, tiredness, and trouble breathing.

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