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Dennie–Marfan syndrome

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Dennie–Marfan syndrome

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Dennie–Marfan syndrome
Specialty	Neurology

Dennie–Marfan syndrome is a syndrome in which there is association of spastic paraplegia of the lower limbs and mental retardation in children with congenital syphilis. Both sexes are affected, and the onset of the disease can be acute or insidious, with slow progression from weakness to quadriplegia. Epilepsy, cataract, and nystagmus may also be found.

The syndrome was described by Charles Clayton Dennie in 1929, and Antoine Marfan in 1936.

External links

v t e Signs and symptoms relating to infectious diseases
Bacterial disease	syphilis Hutchinson's teeth Hutchinson's triad Westphal's sign Clutton's joints Dennie–Marfan syndrome
Viral disease	measles Koplik's spots
Parasitic disease	African trypanosomiasis Winterbottom's sign
General	Meningism Fever Liebermeister's rule Faget sign

Head	Battle's sign Kernig's sign Macewen's sign Myerson's sign Stroop test Hirano body
Other	Intracranial pressure Cushing's triad Lhermitte's sign Charcot's neurologic triad

Combination	Jendrassik maneuver
Legs	Plantar reflex Chaddock reflex Oppenheim's sign Westphal's sign
Arms	Hoffmann's reflex

Other

Arms	Froment's sign carpal tunnel syndrome Tinel's sign Phalen maneuver
Legs	Gowers's sign Hoover's sign Straight leg raise Trendelenburg's sign
Torso	Beevor's sign
General	Pain stimulus