| Combination of | |
|---|---|
| Diclofenac | NSAID |
| Misoprostol | Prostaglandin analog |
| Clinical data | |
| Trade names | Arthrotec |
| MedlinePlus | a699002 |
| License data | |
| Pregnancy category |
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| Routes of administration |
By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
| (verify) | |
Diclofenac/misoprostol, sold under the brand name Arthrotec, is a fixed-dose combination medication that contains:
- Diclofenac sodium: Nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties
- Misoprostol: Gastrointestinal (GI) mucosal protective prostaglandin E1 analog.
In the United Kingdom it is marketed by Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis or osteoarthritis.
The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.
Contraindications
Arthrotec must not be taken during pregnancy, as it may deform or otherwise harm the fetus, or lead to miscarriage. This may be accompanied by potentially dangerous bleeding, possibly requiring surgery and potentially leading to infertility or death.
External links
- "Diclofenac mixture with misoprostol". Drug Information Portal. U.S. National Library of Medicine.
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pyrazolones / pyrazolidines |
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acetic acid derivatives and related substances |
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| oxicams | |
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propionic acid derivatives (profens) |
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n-arylanthranilic acids (fenamates) |
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COX-2 inhibitors (coxibs) |
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| other | |
| NSAID combinations |
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Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
