EF-24

EF-24

Identifiers
IUPAC name (3E,5E)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one
CAS Number	342808-40-6
PubChem CID	9885748
ChemSpider	8061422
UNII	O5YT36MST0
ChEMBL	ChEMBL379849
Chemical and physical data
Formula	C19H15F2NO
Molar mass	311.332 g·mol−1
3D model (JSmol)	Interactive image
SMILES C\1NC/C(=C\C2=CC=CC=C2F)/C(=O)/C1=C/C3=CC=CC=C3F
InChI InChI=1S/C19H15F2NO/c20-17-7-3-1-5-13(17)9-15-11-22-12-16(19(15)23)10-14-6-2-4-8-18(14)21/h1-10,22H,11-12H2/b15-9+,16-10+ Key:NIVYQYSNRUIFIF-KAVGSWPWSA-N

EF-24 is a compound that is a synthetic analogue of curcumin, a bioactive phytochemical from turmeric. Curcumin has antioxidant, antibiotic, anti-inflammatory and anti-cancer properties in vitro but has low potency and very poor bioavailability when taken orally, resulting in limited efficacy. EF-24 was developed to try to improve upon these properties, and has been found to be around 10x more potent than curcumin and with much higher systemic bioavailability. It has never been developed for medical use, though research continues to investigate whether it may be useful as an adjuvant treatment for some cancers alongside conventional chemotherapy drugs.