| Eosinophilic fasciitis | |
|---|---|
| Other names | Shulman syndrome |
| Specialty |
Rheumatology 
|
Eosinophilic fasciitis (/ˌiːəˌsɪnəˈfɪlɪk ˌfæʃiˈaɪtɪs, ˌiːoʊ-, -ˌfæsi-/), also known as Shulman's syndrome, is an inflammatory disease that affects the fascia, other connective tissues, surrounding muscles, blood vessels and nerves. Unlike other forms of fasciitis, eosinophilic fasciitis is typically self-limited and confined to the arms and legs, although it can require treatment with corticosteroids, and some cases are associated with aplastic anemia.
The condition was first characterized in 1974, but it is not yet known whether it is actually a distinct condition or merely a variant presentation of another syndrome. The presentation is similar to that of scleroderma or systemic sclerosis. However, unlike scleroderma, eosinophilic fasciitis affects the deeper fascial layers, rather than the dermis; the characteristic and severe effects of scleroderma and systemic sclerosis, such as Raynaud's syndrome, involvement of the extremities, prominent small blood vessels (telangiectasias), and visceral changes such as swallowing problems, are absent. Nevertheless, the term remains used for diagnostic purposes.
Signs and symptoms
Because the disease is rare and clinical presentations vary, a clear set of symptoms is difficult to define. Severe pain and swelling are often reported, and skin can resemble orange peel in appearance. Less common features include joint pain and carpal tunnel syndrome.
Cause
Most cases are idiopathic, but strenuous exercise, initiation of hemodialysis, infection with Borrelia burgdorferi, and certain medications, such as statins, phenytoin, ramipril, and subcutaneous heparin, may trigger the condition.
Diagnosis
The key to diagnosis is the observation of skin changes in combination with eosinophilia, but the most accurate test is a biopsy of skin, fascia, and muscle.
Treatment
Common treatments include corticosteroids such as prednisone, although medications such as hydroxychloroquine have also been used. Early initiation of treatment usually portends a good prognosis if there is no visceral involvement.
Epidemiology
Typical age of onset is around forty to fifty years, although cases in children have been observed. It remains unclear whether the condition is more common in women or men; patient numbers are small, and studies conflict in their reports of preponderance.
See also
Further reading
- Lakhanpal, Sharad; Ginsburg, William W.; Michet, Clement J.; Doyle, John A.; Moore, S.Breanndan (1988). "Eosinophilic fasciitis: Clinical spectrum and therapeutic response in 52 cases". Seminars in Arthritis and Rheumatism. 17 (4): 221–231. doi:10.1016/0049-0172(88)90008-X. ISSN 0049-0172. PMID 3232080.
- Barnes L, Rodnan GP, Medsger TA, Short D (August 1979). "Eosinophilic fasciitis. A pathologic study of twenty cases". The American Journal of Pathology. 96 (2): 493–518. PMC 2042453. PMID 474708.
- Doyle JA, Ginsburg WW (September 1989). "Eosinophilic fasciitis". The Medical Clinics of North America. 73 (5): 1157–66. doi:10.1016/S0025-7125(16)30625-3. PMID 2671538.
- Michet CJ, Doyle JA, Ginsburg WW (January 1981). "Eosinophilic fasciitis: report of 15 cases". Mayo Clinic Proceedings. 56 (1): 27–34. PMID 7453247.
- Bennett, R M; Herron, A; Keogh, L (1977). "Eosinophilic fasciitis. Case report and review of the literature". Annals of the Rheumatic Diseases. 36 (4): 354–359. doi:10.1136/ard.36.4.354. ISSN 0003-4967. PMC 1006697. PMID 901033.
- Falanga, Vincent; Medsger, Thomas A. (1987). "Frequency, levels, and significance of blood eosinophilia in systemic sclerosis, localized scleroderma, and eosinophilic fasciitis". Journal of the American Academy of Dermatology. 17 (4): 648–656. doi:10.1016/S0190-9622(87)70251-5. ISSN 0190-9622. PMID 3668010.
- Varga J, Kähäri VM (November 1997). "Eosinophilia-myalgia syndrome, eosinophilic fasciitis, and related fibrosing disorders". Current Opinion in Rheumatology. 9 (6): 562–70. doi:10.1097/00002281-199711000-00013. PMID 9375286.
- Kent, Lawrence T.; Cramer, Stewart F.; Moskowitz, Roland W. (1981). "Eosinophilic fasciitis". Arthritis & Rheumatism. 24 (5): 677–683. doi:10.1002/art.1780240508. ISSN 0004-3591. PMID 6972219.
- Moulton SJ, Kransdorf MJ, Ginsburg WW, Abril A, Persellin S (March 2005). "Eosinophilic fasciitis: spectrum of MRI findings". AJR. American Journal of Roentgenology. 184 (3): 975–8. doi:10.2214/ajr.184.3.01840975. PMID 15728627.