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Antidepressant
Eutropoflavin
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    Eutropoflavin

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    Eutropoflavin
    4'-Dimethylamino-7,8-dihydroxyflavone.svg
    Clinical data
    ATC code
    • None
    Identifiers
    • 2-[4-(dimethylamino)phenyl]-7,8-dihydroxy-4H-chromen-4-one
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    Formula C17H15NO4
    Molar mass 297.310 g·mol−1
    3D model (JSmol)
    • CN(C)c1ccc(cc1)c2cc(=O)c3ccc(c(c3o2)O)O
    • InChI=InChI=1S/C17H15NO4/c1-18(2)11-5-3-10(4-6-11)15-9-14(20)12-7-8-13(19)16(21)17(12)22-15/h3-9,19,21H,1-2H3
    • Key:YPAYCZOHGRSGJS-UHFFFAOYSA-N

    Eutropoflavin (4'-Dimethylamino-7,8-dihydroxyflavone) is a synthetic flavone and selective small-molecule agonist of TrkB, the main receptor of brain-derived neurotrophic factor (BDNF), which was derived from structural modification of tropoflavin (7,8-DHF). Relative to tropoflavin, eutropoflavin possesses higher agonistic activity at TrkB, is significantly more potent than tropoflavin both in vitro and in vivo, and has a longer duration of action (peaking at 4 hours and "partially decaying" at 8~16 hours in rodents). The compound has been found to produce neuroprotective and neurogenic effects in the brain and spinal cord as well as antidepressant-like effects in animals.

    See also


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