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Fungicides
Famoxadone
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Famoxadone

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Famoxadone
Famoxadone.svg
Names
IUPAC name
(RS)-5-Methyl-5-(4-phenoxyphenyl)-3-(phenylamino)-1,3-oxazolidine-2,4-dione
Other names
Famoxate; FMX
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.114.714
PubChem CID
UNII
  • InChI=1S/C22H18N2O4/c1-22(16-12-14-19(15-13-16)27-18-10-6-3-7-11-18)20(25)24(21(26)28-22)23-17-8-4-2-5-9-17/h2-15,23H,1H3 checkY
    Key: PCCSBWNGDMYFCW-UHFFFAOYSA-N checkY
  • InChI=1/C22H18N2O4/c1-22(16-12-14-19(15-13-16)27-18-10-6-3-7-11-18)20(25)24(21(26)28-22)23-17-8-4-2-5-9-17/h2-15,23H,1H3
    Key: PCCSBWNGDMYFCW-UHFFFAOYAG
  • O=C2OC(C(=O)N2Nc1ccccc1)(c4ccc(Oc3ccccc3)cc4)C
Properties
C22H18N2O4
Molar mass 374.396 g·mol−1
Melting point 140.3-141.8 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Famoxadone is a fungicide to protect agricultural products against various fungal diseases on fruiting vegetables, tomatoes, potatoes, curcurbits, lettuce and grapes. It is used in combination with cymoxanil. Famoxadone is a QoI, albeit with a chemistry different from most QoIs. (It is an oxazolidine-dione while most are strobilurins.) It is commonly used against Plasmopara viticola,Alternaria solani,Phytophthora infestans, and Septoria nodorum.

Molecular interaction

Famoxadone is of lesser interaction strength at the Qp pocket than some other QoIs, for example, azoxystrobin. This is because azoxystrobin and such interact more centrally in the Qp pocket than does famoxadone.

Resistance management

Although it has a different chemistry, famoxadone shows full cross-resistance with the rest of the main FRAC group 11 that it belongs to, which is almost entirely strobs. It has not shown cross-resistance with the 11A subgroup however. As with all QoIs there is a high risk of resistance development and so pesticide stewardship is important.

Populations of P. infestans and A. solani in northern and western Europe are not known to be resistant to famoxadone.

External links

  • Famoxadone in the Pesticide Properties DataBase (PPDB)



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