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Serotonin–norepinephrine reuptake inhibitor
Fezolamine
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    Fezolamine

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    Fezolamine
    Fezolamine Structure.svg
    Clinical data
    Routes of
    administration    		 Oral
    ATC code
    • none
    Legal status
    Legal status
    • In general: uncontrolled
    Identifiers
    • 3-(3,4-Diphenyl- 1H-pyrazol- 1-yl)- N,N-dimethylpropan- 1-amine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C20H23N3
    Molar mass 305.425 g·mol−1
    3D model (JSmol)
    • n1c(c(cn1CCCN(C)C)c2ccccc2)c3ccccc3

    Fezolamine (Win-41,528-2) is a drug which was investigated by Sterling Drug as an antidepressant in the 1980s. The isomeric N,N-dimethyl-4,5-diphenyl-1H-pyrazole-1-propanamine was completely inactive in the primary antidepressant screens.

    It acts as a serotonin, norepinephrine, and dopamine reuptake inhibitor, with 3- to 4-fold preference for the former neurotransmitter. It was found to be effective and well tolerated in clinical trials but was never marketed.

    See also


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