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Abandoned drugs
Filaminast
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    Filaminast

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    Filaminast
    Filaminast.svg
    Clinical data
    ATC code
    • None
    Legal status
    Legal status
    • Development terminated
    Identifiers
    • [(E)-1-(3-Cyclopentyloxy-4-methoxyphenyl)ethylideneamino] carbamate
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    KEGG
    Chemical and physical data
    Formula C15H20N2O4
    Molar mass 292.335 g·mol−1
    3D model (JSmol)
    • CC(=NOC(=O)N)C1=CC(=C(C=C1)OC)OC2CCCC2

    Filaminast (code name WAY-PDA 641) was a drug candidate developed by Wyeth-Ayerst. It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts. It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.

    See also


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