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Flocoumafen
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IUPAC name
2-Hydroxy-3-[3-[4-([4-(trifluoromethyl)phenyl]methoxy)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl] chromen-4-one
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Identifiers | |
3D model (JSmol)
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ECHA InfoCard | 100.102.053 |
KEGG |
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PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C33H25F3O4 | |
Molar mass | 542.554 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Flocoumafen is a fluorinated, second-generation anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first-generation anticoagulants can be adequately controlled with flocoumafen. It was synthesized in 1984 by Shell International Chemical.
Toxicity
To most rodents LD50 is 1 mg/kg, but it can vary a lot between species: from 0.12 mg/kg: Microtus arvalis to more than 10 mg/kg Acomys cahirinus. For dogs: 0.075 - 0.25 mg/kg.
Antidote
Antidote is vitamin K1.
External links
- ICSC: Flocoumafen
- PubChem: Flocoumafen
- Kyoto Encyclopedia of Genes and Genomes (KEGG): Flocoumafen
- ChemBlink: Flocoumafen
Anticoagulants / Vitamin K antagonists |
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