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Alcon
Fluorescite
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Fluorescite

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Fluorescein
Fluorescin in dropper.jpg
Fluorescein drops being put in the eye before examination
Clinical data
Pronunciation /ˈflʊərəsiːn/
Trade names Fluorescite, AK-Fluor, BioGlo, others
License data
Routes of
administration		 Eye drops, intravenous, by mouth
Drug class Diagnostic agent
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
  • 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
Chemical and physical data
Formula C20H12O5
Molar mass 332.311 g·mol−1
3D model (JSmol)
  • C1=CC=C2C(=C1)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
  • InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)24-18-10-12(22)6-8-16(18)20(15)14-4-2-1-3-13(14)19(23)25-20/h1-10,21-22H
  • Key:GNBHRKFJIUUOQI-UHFFFAOYSA-N

Fluorescein is used to help in the diagnosis of a number of eye problems. When applied as a drop or within a strip of paper to the surface of the eye it is used to help detect eye injuries such as foreign bodies and corneal abrasions. When given by mouth or injection into a vein it is used to help evaluate the blood vessels in the back of the eye during fluorescein angiography.

When applied to the surface of the eye, side effects may include a brief period of blurry vision and discoloration of contact lenses of the soft type. When used by mouth or injection, side effects may include headache, nausea, and a change to the color of the skin for a brief period of time.Allergic reactions may rarely occur. Fluorescein is a dye which is taken up by damaged cornea such that the area appears green under cobalt blue light. There is also a version that comes premixed with lidocaine.

Fluorescein was first made in 1871. It is on the World Health Organization's List of Essential Medicines.

Brand names

It is also sold as a combination drug with oxybuprocaine under the brand name Altafluor Benox.

Other animals

It is also sometimes administered to pets in multi-pet environments to determine which pet needs behavioral modification.

External links


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