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Foliglurax
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    Foliglurax

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    Foliglurax
    Foliglurax tautomer skeletal.svg
    Clinical data
    Other names DT2331; PXT-002331; PXT-2331
    Identifiers
    • 4-[3-[4-nitroso-2-(5H-thieno[3,2-c]pyridin-6-ylidene)chromen-6-yl]propyl]morpholine
    CAS Number
    PubChem CID
    ChemSpider
    Chemical and physical data
    Formula C23H23N3O3S
    Molar mass 421.52 g·mol−1
    3D model (JSmol)
    • C1COCCN1CCCC2=CC3=C(C=C2)OC(=C4C=C5C(=CN4)C=CS5)C=C3N=O
    • InChI=1S/C23H23N3O3S/c27-25-19-13-22(20-14-23-17(15-24-20)5-11-30-23)29-21-4-3-16(12-18(19)21)2-1-6-26-7-9-28-10-8-26/h3-5,11-15,24H,1-2,6-10H2
    • Key:XHRLGFLGWZIPEE-UHFFFAOYSA-N

    Foliglurax (developmental code names PXT-002331, DT2331) is a positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4), which is under development by Prexton Therapeutics for the treatment of Parkinson's disease. It reached phase II clinical trials, but while it was found to be safe and showed some signs of clinical improvement, it failed to sufficiently distinguish itself from placebo to meet the study endpoints.

    The other tautomeric form of foliglurax.



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