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Free fraction
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The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:
- Plasma free fraction, previously referred to as ƒ1, is now referred to as ƒP according to consensus nomenclature.
- Tissue free fraction (ƒND), previously referred to as ƒ2
The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.
See also
Others
- Milak MS, Severance AJ, Ogden RT, Prabhakaran J, Kumar JS, Majo VJ, Mann JJ, Parsey RV (2008). "Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET". J. Nucl. Med. 49 (4): 587–596. doi:10.2967/jnumed.107.046540. PMC 3580231. PMID 18344443.