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Free fraction
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    Free fraction

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    The free fraction is a parameter in pharmacokinetics and receptor-ligand kinetics. One speaks of two different free fractions:

    • Plasma free fraction, previously referred to as ƒ1, is now referred to as ƒP according to consensus nomenclature.
    • Tissue free fractionND), previously referred to as ƒ2

    The plasma free fraction is the fraction of the ligand at equilibrium in blood plasma that is not bound to plasma proteins.

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