Gadopiclenol

Gadopiclenol

Clinical data
Trade names	Elucirem, Vueway
AHFS/Drugs.com	Micromedex Detailed Consumer Information
License data	US DailyMed: Gadopiclenol
Routes of administration	Intravenous
ATC code	V08CA12 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Metabolism	None
Excretion	Kidneys
Identifiers
IUPAC name 2-[3,9-bis[1-carboxylato-4-(2,3-dihydroxypropylamino)-4-oxobutyl]-3,6,9,15-tetrazabicyclo[9.3.1]pentadeca-1(15),11,13-trien-6-yl]-5-(2,3-dihydroxypropylamino)-5-oxopentanoate;gadolinium(3+)
CAS Number	933983-75-6
PubChem CID	16223405
ChemSpider	17350646
UNII	S276568KOY
KEGG	D12435
Chemical and physical data
Formula	C35H54GdN7O15
Molar mass	970.10 g·mol−1
3D model (JSmol)	Interactive image
SMILES [Gd+3].OCC(O)CNC(=O)CCC(N1CCN(Cc2cccc(CN(CC1)C(CCC(=O)NCC(O)CO)C(=O)[O-])n2)C(CCC(=O)NCC(O)CO)C(=O)[O-])C(=O)[O-]
InChI InChI=1S/C35H57N7O15.Gd/c43-19-24(46)14-36-30(49)7-4-27(33(52)53)40-10-12-41(28(34(54)55)5-8-31(50)37-15-25(47)20-44)17-22-2-1-3-23(39-22)18-42(13-11-40)29(35(56)57)6-9-32(51)38-16-26(48)21-45;/h1-3,24-29,43-48H,4-21H2,(H,36,49)(H,37,50)(H,38,51)(H,52,53)(H,54,55)(H,56,57);/q;+3/p-3 Key:GNRQMLROZPOLDG-UHFFFAOYSA-K

Gadopiclenol, sold under the brand name Elucirem among others, is a contrast agent used with magnetic resonance imaging (MRI) to detect and visualize lesions with abnormal vascularity in the central nervous system and in the body. Gadopiclenol is a paramagnetic macrocyclic non-ionic complex of gadolinium.

Gadopiclenol was approved for medical use in the United States in September 2022.

Names

Gadopiclenol is the international nonproprietary name (INN).

External links

• Clinical trial number NCT03996447 for "Efficacy and Safety of Gadopiclenol for Central Nervous System (CNS) Magnetic Resonance Imaging (MRI) (PICTURE)" at ClinicalTrials.gov
• Clinical trial number NCT03986138 for "Efficacy and Safety of Gadopiclenol for Body Magnetic Resonance Imaging (MRI) (PROMISE)" at ClinicalTrials.gov