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Gadoxetic acid
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Gadoxetic acid

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Gadoxetic acid
Gadoxetic acid.png
Clinical data
Trade names Eovist
Other names Gadoxetate disodium (USAN US)
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
Identifiers
  • 2-[[2-[bis(2-oxido-2-oxoethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino]acetate; gadolinium(+3) cation
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
Formula C23H30GdN3O11
Molar mass 681.75 g·mol−1
3D model (JSmol)
  • CCOc1ccc(cc1)C[C@@H](CN(CCN(CC(=O)O)CC(=O)[O-])CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Gd+3]
  • InChI=1S/C23H33N3O11.Gd/c1-2-37-18-5-3-16(4-6-18)9-17(26(14-22(33)34)15-23(35)36)10-24(11-19(27)28)7-8-25(12-20(29)30)13-21(31)32;/h3-6,17H,2,7-15H2,1H3,(H,27,28)(H,29,30)(H,31,32)(H,33,34)(H,35,36);/q;+3/p-3/t17-;/m0./s1
  • Key:PCZHWPSNPWAQNF-LMOVPXPDSA-K
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Gadoxetic acid is a gadolinium-based MRI contrast agent. Its salt, gadoxetate disodium, is marketed as Primovist in Europe and Eovist in the United States by Bayer HealthCare Pharmaceuticals.

Medical uses

It is used to increase the T1 signal intensity while imaging the liver lesions such as benign cysts, haemangioma, and liver cancer. It is excreted into bile by active secretion.

Pharmacokinetics

In those with end-stage renal failure, the clearance rate is only 17% with terminal half-life of 12 times longer than the those with normal renal function.

See also

External links



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