HDAC1

HDAC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKX, 5ICN
Identifiers
Aliases	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
External IDs	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
Gene location (Human) Chr. Chromosome 1 (human) Band 1p35.2-p35.1 Start 32,292,083 bp End 32,333,635 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D2.2|4 63.26 cM Start 129,409,897 bp End 129,436,506 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum lymph node pylorus right uterine tube cecum gums appendix islet of Langerhans duodenum cavity of mouth Top expressed in morula bone marrow yolk sac thymus placenta neural tube ganglionic eminence stomach lip jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding NAD-dependent histone deacetylase activity (H3-K14 specific) transcription corepressor activity histone deacetylase activity protein N-terminus binding DNA-binding transcription factor activity protein deacetylase activity histone deacetylase binding transcription cis-regulatory region binding NF-kappaB binding deacetylase activity protein binding nucleosomal DNA binding enzyme binding hydrolase activity core promoter sequence-specific DNA binding p53 binding transcription factor binding RNA polymerase II core promoter sequence-specific DNA binding DNA binding chromatin binding Krueppel-associated box domain binding E-box binding promoter-specific chromatin binding Cellular component cytoplasm NuRD complex cytosol histone deacetylase complex Sin3 complex nucleoplasm nucleus chromatin heterochromatin transcription regulator complex transcription repressor complex protein-containing complex neuronal cell body Sin3-type complex Biological process hair follicle placode formation epidermal cell differentiation chromatin remodeling regulation of transcription, DNA-templated rhythmic process negative regulation of androgen receptor signaling pathway embryonic digit morphogenesis negative regulation of apoptotic process blood coagulation negative regulation of transcription by RNA polymerase II eyelid development in camera-type eye circadian regulation of gene expression negative regulation of gene expression positive regulation of transcription, DNA-templated odontogenesis of dentin-containing tooth protein deacetylation histone H4 deacetylation fungiform papilla formation negative regulation of myotube differentiation viral process histone deacetylation negative regulation of canonical Wnt signaling pathway positive regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of signal transduction by p53 class mediator DNA methylation-dependent heterochromatin assembly beta-catenin-TCF complex assembly chromatin organization positive regulation of cell population proliferation negative regulation of transcription, DNA-templated histone H3 deacetylation regulation of megakaryocyte differentiation regulation of transcription by RNA polymerase II endoderm development circadian rhythm hippocampus development neuron differentiation negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of oligodendrocyte differentiation regulation of endopeptidase activity regulation of amyloid-beta clearance negative regulation of intrinsic apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3065 433759 Ensembl ENSG00000116478 ENSMUSG00000028800 UniProt Q13547 O09106 RefSeq (mRNA) NM_004964 NM_008228 RefSeq (protein) NP_004955 NP_032254 Location (UCSC) Chr 1: 32.29 – 32.33 Mb Chr 4: 129.41 – 129.44 Mb PubMed search
Wikidata
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Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Model organisms

Model organisms have been used in the study of HDAC1 function. A conditional knockout mouse line, called Hdac1^{tm1a(EUCOMM)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty five tests were carried out and two phenotypes were reported. A reduced number of homozygous mutant embryos were identified during gestation, and none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.

Interactions

HDAC1 has been shown to interact with:

See also

• Histone deacetylase
• Histone deacetylase inhibitor

Further reading

External links

• HDAC1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)