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HLA-DOA
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HLA-DOA

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HLA-DOA
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HLA-DOA, HLA-DNA, HLA-DZA, HLADZ, major histocompatibility complex, class II, DO alpha
External IDs OMIM: 142930 MGI: 95924 HomoloGene: 1601 GeneCards: HLA-DOA
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002119
NM_015851

NM_008206

RefSeq (protein)

NP_002110

n/a

Location (UCSC) Chr 6: 33 – 33.01 Mb Chr 17: 34.31 – 34.31 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen, DO alpha chain is a protein that in humans is encoded by the HLA-DOA gene.

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.

Further reading


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