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Abandoned drugs
HT-2157
Другие языки:

HT-2157

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HT-2157
Structural formula
Space-filling model
Clinical data
ATC code
  • none
Identifiers
  • 1-Phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
Chemical and physical data
Formula C21H13F3N2O
Molar mass 366.343 g·mol−1
3D model (JSmol)
  • c14ccccc4n(-c3ccccc3)c(=O)c1=N\c(c2)cccc2C(F)(F)F
  • InChI=1S/C21H13F3N2O/c22-21(23,24)14-7-6-8-15(13-14)25-19-17-11-4-5-12-18(17)26(20(19)27)16-9-2-1-3-10-16/h1-13H/b25-19+
  • Key:TXCGMRVPXUBHAL-NCELDCMTSA-N

HT-2157 (former development code SNAP-37889) is a drug which acts as a selective non-peptide antagonist for the receptor GAL-3, which is usually activated by the neuropeptide galanin. Blocking this receptor with HT-2157 produced increased serotonin release, as well as producing antidepressant and anxiolytic effects in animal studies, and it was also being researched for treatment of cognitive dysfunction. All human clinical trials were terminated due to safety concerns however, and new GAL-3 antagonists are now being sought instead.



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