IGHV@
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Ig heavy chain V-III region VH26 is a protein that in humans is encoded by the IGHV@ gene.
IGHV is the immunoglobulin heavy chain variable region genes; in B-cell neoplasms like chronic lymphocytic leukemia, mutations of IGHV are associated with better responses to some treatments and with prolonged survival.
See also
Further reading
- Matsuda F, Shin EK, Hirabayashi Y, et al. (1990). "Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments". EMBO J. 9 (8): 2501–6. doi:10.1002/j.1460-2075.1990.tb07429.x. PMC 552279. PMID 2114977.
- Cherif D, Berger R (1991). "New localizations of VH sequences by in situ hybridization with biotinylated probes". Genes Chromosomes Cancer. 2 (2): 103–8. doi:10.1002/gcc.2870020205. PMID 2126193. S2CID 22489747.
- Toyonaga B, Yoshikai Y, Vadasz V, et al. (1986). "Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain". Proc. Natl. Acad. Sci. U.S.A. 82 (24): 8624–8. doi:10.1073/pnas.82.24.8624. PMC 390970. PMID 3866244.
- Matthyssens G, Rabbitts TH (1981). "Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region". Proc. Natl. Acad. Sci. U.S.A. 77 (11): 6561–5. doi:10.1073/pnas.77.11.6561. PMC 350325. PMID 6450418.
- Mariette X, Tsapis A, Brouet JC (1993). "Nucleotidic sequence analysis of the variable domains of four human monoclonal IgM with an antibody activity to myelin-associated glycoprotein". Eur. J. Immunol. 23 (4): 846–51. doi:10.1002/eji.1830230412. PMID 7681398. S2CID 38756102.
- Boursier L, Su W, Spencer J (2003). "Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments". Mol. Immunol. 39 (16): 1025–34. doi:10.1016/S0161-5890(03)00033-6. PMID 12749909.
- Nakamura N, Nakamura S, Yamaguchi M, et al. (2005). "CD5+ diffuse large B-cell lymphoma consists of germline cases and hypermutated cases in the immunoglobulin heavy chain gene variable region". Int. J. Hematol. 81 (1): 58–61. doi:10.1532/IJH97.04119. PMID 15717690. S2CID 22639228.
- Suárez E, Magadán S, Sanjuán I, et al. (2006). "Rearrangement of only one human IGHV gene is sufficient to generate a wide repertoire of antigen specific antibody responses in transgenic mice". Mol. Immunol. 43 (11): 1827–35. doi:10.1016/j.molimm.2005.10.015. PMID 16343622.
- Balogh Z, Reiniger L, Deák L, et al. (2007). "IgVH gene mutation status and genomic imbalances in chronic lymphocytic leukaemia with increased prolymphocytes (CLL/PL)". Hematological Oncology. 25 (2): 90–5. doi:10.1002/hon.812. PMID 17410523. S2CID 19587621.