Indian childhood cirrhosis
Indian childhood cirrhosis is a chronic liver disease of childhood characterised by cirrhosis of the liver associated with the deposition of copper in the liver. It primarily affects children of 1–3 years of age and has a genetic predisposition. It had a very high case fatality in the past, but has eventually become preventable, treatable "with D-penicillamine in the treatment of 85 biopsy proven cases of Indian childhood cirrhosis", according to the Indian Journal of Pediatrics. "The drug significantly (P< 0.002) reduced the serum and hepatic copper content and simultaneously there was improvement in clinical and symptomatic aspects. This therapy was compared with the conventional corticosteroid therapy."
It remains a part of the differential diagnosis of Wilson's disease.
See also
Further reading
- Paton, A (October 17, 1981). "Indian childhood cirrhosis". Br Med J (Clin Res Ed). 283 (6298): 1006. doi:10.1136/bmj.283.6298.1006. PMC 1507261. PMID 6794739.
- Raju, VB; Sundaravalli, N; Sriramachari, S (Nov–Dec 1980). "Indian childhood cirrhosis: clinical features, prognosis and treatment". Indian Journal of Pediatrics. 47 (389): 537–41. doi:10.1007/BF02822546. PMID 7262970. S2CID 30670129.
- Bavdekar, AR; Bhave, SA; Pradhan, AM; Pandit, AN; Tanner, MS (1996). "Long term survival in Indian childhood cirrhosis treated with D-penicillamine". Archives of Disease in Childhood. 74 (1): 32–35. doi:10.1136/adc.74.1.32. PMC 1511595. PMID 8660042.
- Nayak N.C.; Chitale A.R. (2013). "Indian childhood cirrhosis (ICC) & ICC-like diseases: The changing scenario of facts versus notions". Indian J. Med. Res. 137 (6): 1029–42. PMC 3734708. PMID 23852284.