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Integrin alpha 3

Integrin alpha 3

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ITGA3
Identifiers
Aliases ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7
External IDs OMIM: 605025 MGI: 96602 HomoloGene: 21129 GeneCards: ITGA3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002204
NM_005501

NM_013565
NM_001306071
NM_001306162

RefSeq (protein)

NP_002195

NP_001293000
NP_001293091
NP_038593

Location (UCSC) Chr 17: 50.06 – 50.09 Mb Chr 11: 94.94 – 94.97 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').

Interactions

CD49c has been shown to interact with:

Further reading

External links



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