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Abandoned drugs
Irampanel
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    Irampanel

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    Irampanel
    Irampanel.svg
    Clinical data
    ATC code
    • None
    Identifiers
    • N,N-Dimethyl-2-[2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenoxy]ethanamine
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C18H19N3O2
    Molar mass 309.369 g·mol−1
    3D model (JSmol)
    • CN(C)CCOc1ccccc1c2nc(no2)c3ccccc3
    • InChI=1S/C18H19N3O2/c1-21(2)12-13-22-16-11-7-6-10-15(16)18-19-17(20-23-18)14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3
    • Key:QZULPCPLWGCGSL-UHFFFAOYSA-N

    Irampanel (INN, code name BIIR-561) is a drug which acts as a dual noncompetitive antagonist of the AMPA receptor and neuronal voltage-gated sodium channel blocker. It was under development by Boehringer Ingelheim for the treatment of acute stroke/cerebral ischemia but never completed clinical trials for this indication. Irampanel was also trialed, originally, for the treatment of epilepsy and pain, but these indications, too, were abandoned, and the drug was ultimately never marketed.



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