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CB1 receptor agonists
JWH-149
Другие языки:

    JWH-149

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    JWH-149
    JWH-149.png
    Legal status
    Legal status
    Identifiers
    • (4-Methyl-1-naphthalenyl)(2-methyl-1-pentyl-1H-indol-3-yl)methanone
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C26H27NO
    Molar mass 369.508 g·mol−1
    3D model (JSmol)
    • c4cccc1c4c(ccc1C)C(=O)c3c2ccccc2n(c3C)CCCCC
    • InChI=1S/C26H27NO/c1-4-5-10-17-27-19(3)25(23-13-8-9-14-24(23)27)26(28)22-16-15-18(2)20-11-6-7-12-21(20)22/h6-9,11-16H,4-5,10,17H2,1-3H3
    • Key:JTJAMXUOXJGSCW-UHFFFAOYSA-N

    JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than six times selectivity over the CB1 subtype.

    In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-149 are Schedule I Controlled Substances.

    See also


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