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CB1 receptor agonists
JWH-249
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    JWH-249

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    JWH-249
    JWH-249.svg
    Legal status
    Legal status
    Identifiers
    • 2-(2-Bromophenyl)-1-(1-pentylindol-3-yl)ethanone
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    CompTox Dashboard (EPA)
    Chemical and physical data
    Formula C21H22BrNO
    Molar mass 384.317 g·mol−1
    3D model (JSmol)
    • CCCCCn1cc(c2c1cccc2)C(=O)Cc3ccccc3Br
    • InChI=1S/C21H22BrNO/c1-2-3-8-13-23-15-18(17-10-5-7-12-20(17)23)21(24)14-16-9-4-6-11-19(16)22/h4-7,9-12,15H,2-3,8,13-14H2,1H3 checkY
    • Key:CGQRVOHECAULLB-UHFFFAOYSA-N checkY
     ☒NcheckY (what is this?)  (verify)

    JWH-249 (1-pentyl-3-(2-bromophenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 2.4 times selectivity for CB1 with a Ki of 8.4 ± 1.8 nM and 20 ± 2 nM at CB2. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-methyl compound JWH-251, JWH-249 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds.

    In the United States, CB1 receptor agonists of the 3-phenylacetylindole class such as cannabipiperidiethanone are Schedule I Controlled Substances.

    See also


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