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Anticonvulsant
Licarbazepine
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    Licarbazepine

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    Licarbazepine
    Licarbazepine.svg
    Top: (R)-(−)-licarbazepine
    Bottom: (S)-(+)-licarbazepine
    Clinical data
    ATC code
    • None
    Pharmacokinetic data
    Protein binding <40%
    Metabolites Glucuronides
    Excretion Mainly renal
    Identifiers
    • (RS)-10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    KEGG
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard 100.122.427
    Chemical and physical data
    Formula C15H14N2O2
    Molar mass 254.289 g·mol−1
    3D model (JSmol)
    Chirality Racemic mixture
    • NC(=O)N1c2ccccc2CC(O)c3ccccc13
    • InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
    • Key:BMPDWHIDQYTSHX-UHFFFAOYSA-N

    Licarbazepine is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an enantiomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.


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