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Abandoned drugs
Licofelone
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Licofelone

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Licofelone
Licofelone structure.svg
Legal status
Legal status
  • Investigational
Identifiers
  • [6-(4-Chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.222.821
Chemical and physical data
Formula C23H22ClNO2
Molar mass 379.88 g·mol−1
  • InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27) ☒N
  • Key:UAWXGRJVZSAUSZ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Licofelone is a dual COX/LOX inhibitor that was studied in clinical trials as a treatment for osteoarthritis and which was under development by Merckle GmbH with partners Alfa Wassermann and Lacer.

Licofelone is both an analgesic and an anti-inflammatory. Inhibition of 5-lipoxygenase (5-LOX) may reduce the gastrointestinal toxicity associated with other nonsteroidal anti-inflammatory drugs (NSAID), which only inhibit cyclooxygenase (COX). Licofelone is the first drug to inhibit both.

Phase III trials for osteoarthritis were conducted in the early 2000s, but results were mixed and the drug has never been submitted for regulatory approval.


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