List of adverse effects of chlorpromazine
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Chlorpromazine includes the following list of adverse effects (serious adverse effects appear in bold):
Very common
- Sedation (cf. "Thorazine shuffle" – a shuffling gait due to sedation)
- Somnolence
- Extrapyramidal symptoms
- Weight gain
- Orthostatic hypotension
- Dry mouth
- Constipation
Common
- ECG changes
- Contact dermatitis
- Sensitivity to light
- Urticaria (hives)
- Maculopapular rash
- Petechia or edema
- Hyperprolactinaemia
- Impaired thermoregulation
- Hyperglycaemia
- Other hypothalamic abnormalities
- Blurred vision
- Confusion
- Raised ANA titre
- Positive SLE cells
- Mydriasis
- Atonic colon
- Seizure
- Psychomotor agitation|Agitation (restlessness)
- Pain at the injection site
- Injection site abscess
Uncommon
- Miosis
- Urinary retention
- Nasal congestion
- Nausea
- Obstipation
- Arrhythmias
- Skin pigmentation
- Glycosuria
- Hypoglycaemia
- Paralytic ileus
Rare
- Agranulocytosis
- Haemolytic anaemia
- Aplastic anaemia
- A-V block
- Hypertensive crises
- Thrombocytopenic purpura
- Exfoliative dermatitis
- Toxic epidermal necrolysis
- Systemic lupus erythematosus
- Syndrome of inappropriate secretion of antidiuretic hormone (SIADH)
- Water retention
- Cholestatic jaundice
- Liver injury
- Neuroleptic malignant syndrome
- Myasthenia gravis
Unknown frequency
- Leucopaenia
- Eosinophilia
- Pancytopaenia
- Priapism
- Photophobia
- Corneal deposits
- Respiratory depression
- Ventricular tachycardia
- QT interval prolongation
- Atrial fibrilation
- Hyperthermia
- Hypothermia
- Galactorrhoea
- Breast enlargement in either sex
- False-positive pregnancy tests
- Allergic reaction
- Fits
- Cerebral oedema
- Urinary incontinence
- Coagulation defects
- Nightmares
- Abnormality of cerebrospinal fluid proteins
- Dysphoria
- Catatonic excitement
- Narrow angle glaucoma
- Optic atrophy
- Pigmentary retinopathy
- Amenorrhoea
- Infertility
- Tardive dyskinesia