List of adverse effects of valproate semisodium
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Adverse effects by frequency for use of valproate semisodium.
Very common (>10% frequency)
- Nausea
- Tremor
Common (1-10% frequency)
- Liver injury
- Gastralgia
- Diarrhoea
- Extrapyramidal (movement) disorder
- Stupor
- Somnolence
- Convulsion
- Memory impairment
- Headache
- Nystagmus
- Confusional state
- Aggression
- Agitation
- Impaired attention
- Hyponatraemia
- Anaemia
- Thrombocytopaenia
- Hypersensitivity
- Transient and/or dose-related hair loss
- Dysmenorrhea
- Haemorrhage (bleeding)
- Weight gain
Uncommon (0.01-0.1% frequency)
- Pancreatitis (sometimes lethal)
- Coma
- Lethargy
- SIADH
- Pancytopenia
- Leucopenia
- Rash
- Angioedema
- Amenorrhoea (absence of menstrual cycle)
- Vasculitis
- Peripheral oedema
- Reduced bone mineral density
- Osteopaenia
- Osteoporosis
- Pleural effusions
- Gingival enlargement
Rare (<0.01% frequency)
- Reversible dementia
- Reversible cerebral atrophy
- Abnormal behaviour
- Psychomotor hyperactivity
- Learning disorder
- Hyperammonaemia
- Hypothyroidism
- Bone marrow failure
- Toxic epidermal necrolysis
- Stevens–Johnson syndrome
- Erythema multiforme
- DRESS syndrome
- Male infertility
- Polycystic ovaries
- Enuresis
- Reversible Fanconi syndrome
- Coagulation abnormalities
- Systemic lupus erythematosus
- Gynaecomastia