List of investigational hallucinogens and entactogens
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This is a list of investigational hallucinogens and entactogens, or hallucinogens and entactogens that are currently under formal development for clinical use but are not yet approved. Many of the indications are not for continuous medication therapy but rather for medication-assisted psychotherapy or short-term use only. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Hallucinogens
Psychedelics
- Dimethyltryptamine (DMT) – addiction, substance-related disorders – Entheon Biomedical [1]
- Lysergic acid diethylamide (LSD; "Lucy") – anxiety disorders, attention-deficit hyperactivity disorder – MAPS, MindMed [2] [3] [4]
- Psilocybin (COMP-360, PB-1818, PSY-0.1–0.6, MYCO-001) – bipolar depression, depressive disorders, major depressive disorder, somatoform disorders – COMPASS Pathways, PsyBio Therapeutics, Mydecine [5] [6] [7] [8] [9] [10] [11]
Dissociatives
- Arketamine ((R)-ketamine; HR-071603) – depressive disorders – Jiangsu Hengrui Medicine [12]
- Esketamine ((S)-ketamine; PG061) – bipolar depression, depressive disorders – Celon Pharma [13]
- Ketamine (ELE-Ket+, R-107, SHX-001, PMI-100, PMI-150, SLS-002, TUR-002; Ereska) – major depressive disorder, suicidal ideation, cluster headaches – Eleusis, Douglas Pharmaceuticals, Shenox Pharmaceuticals, CCH Pharmaceuticals, Seelos Therapeutics [14] [15] [16] [17] [18]
Others/mixed
- 18-Methoxycoronaridine (18-MC) – leishmaniasis, opioid-related disorders, substance-related disorders – MindMed [19]
- Ibogaine – opioid-related disorders – ATAI Life Sciences/DemeRx [20]
Entactogens
- Midomafetamine (MDMA; "Ecstasy") – post-traumatic stress disorders, mood disorders, substance-related disorders, social anxiety in autism – MAPS, MindMed [21] [22] [23]
- MYCO-002 – MDMA-like entactogen – Mydecine [24]
Others/unsorted
- Ketanserin – LSD neutralization – MindMed [25]
Mixed
- Lysergic acid diethylamide/midomafetamine (LSD/MDMA) – psychedelic-assisted psychotherapy – MindMed [26] [27]