List of investigational sexual dysfunction drugs

This is a list of investigational sexual dysfunction drugs, or drugs that are currently under development for clinical treatment of sexual dysfunction but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.

Atrophic vaginitis

• Estetrol (E4; Donesta) – estrogen receptor agonist Estetrol - Mithra Pharmaceuticals - AdisInsight
• Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulatorLasofoxifene - Sermonix Pharmaceuticals - AdisInsight

Erectile dysfunction

• HCP-1302 – undefined mechanism of actionHCP 1302 - AdisInsight
• Nitroglycerin gel (Eroxon, Futura, MED-2001–MED-2005) – nitric oxide donorNitroglycerin gel - Futura Medical - AdisInsight
• Tadalafil/tamsulosin (HCP-1303, CKD-397, YBH-1603)Tadalafil/tamsulosin - Hanmi Pharmaceutical - AdisInsightTadalafil/tamsulosin - Ildong Pharmaceutical - AdisInsightTadalafil/tamsulosin - Chong Kun Dang - AdisInsightTadalafil/tamsulosin - Yungjin Pharmaceutical - AdisInsight
• TT-701 (LY-2452473) – selective androgen receptor modulatorOPK 88004 - AdisInsight

Female anorgasmia

• Testosterone low-dose intranasal (MPP-14, TBS-2, Noseafix, Tefina) – androgen receptor agonist Testosterone intranasal (low-dose) - Acerus Pharmaceuticals - AdisInsight

Female sexual dysfunction

• BP-101 – undefined mechanism of action BP 101 - Ovoca Bio - AdisInsight
• Bupropion/trazodone (S1P-104, S1P-205, Lorexys, Orexa) – norepinephrine reuptake inhibitor, nicotinic acetylcholine receptor antagonist, 5-HT_2A receptor antagonist, α₁-adrenergic receptor antagonist, weak serotonin reuptake inhibitorBupropion/trazodone - AdisInsight
• Buspirone/testosterone (Lybridos) – 5-HT_1A receptor partial agonist and androgen receptor agonist Buspirone/testosterone - Emotional Brain - AdisInsight
• Lasofoxifene (CP-336156, CP-336156-CB, Fablyn, Oporia) – selective estrogen receptor modulator Lasofoxifene - Sermonix Pharmaceuticals - AdisInsight
• PL-6983 – selective MC₄ receptor agonist Research programme: sexual dysfunction therapy - Palatin Technologies - AdisInsight
• Sildenafil/testosterone (Lybrido) – PDE5 inhibitor and androgen receptor agonist Sildenafil/testosterone - Emotional Brain - AdisInsight
• TGFK09SD – 5-HT_1A receptor agonist TGFK 09SD - AdisInsight

Premature ejaculation

• Clomipramine/sildenafil (CDFR-0812) – serotonin reuptake inhibitor and PDE5 inhibitor Clomipramine/sildenafil - CTC Bio - AdisInsight
• DA-8031 – serotonin reuptake inhibitor DA 8031 - AdisInsight
• IX-01 – oxytocin receptor antagonist Cligosiban - Ixchelsis - AdisInsight
• OnabotulinumtoxinA (botulinum toxin A, Botox) – acetylcholine release inhibitorOnabotulinum toxin A - AbbVie - AdisInsight

Unspecified

• Vilazodone (Viibryd, EMD-68843, SB-659746A) – 5-HT_1A receptor partial agonist and serotonin reuptake inhibitor Vilazodone - AbbVie - AdisInsight

See also

• List of investigational drugs

External links

• AdisInsight - Springer